Objective: To evalrate the effect ofpatients suffered from megrin with tabellae kallikrcin treatment. Method: 86 patients who caught megrim were devided into two groups: Tabellae kallikrein group and tabellae pizo.tifen group. TPK group received Tabellae kallikein treatment three times daily, each time with three tablets (56 unit per taolet). The other group took Tabellae pizofifen 0. 5mg eath time, three times daily Each group had a three-month treatment duration. Result: Total effective rate in TPK grorp is 91.3%, along with Tabellae Pizotifen group accounting for 65.0%. Futhermore, TPK group has a megnn reoccurent proportion of 28.3%against 80.0%in Tabellae Pizotifen grorp. Besides, 11 patients in TPK group had mild side effects, but in Tabellae Pizotifen group there were 16 patients with that of a various scales. BY Ridit analysis and X2 test, the deviation between the two groups were statistically significant. (P＜ 0.01 ). Conclusion: TPK was better than Pizotifen in megrin treatment with its characters of more security, higher quality and Iower reoccurence.